EMPIRIC TREATMENT OF MALE INFERTILITY
Our Male Infertility Specialist:
Most of the studies were performed in vitro. Available data do not confirm any positive effects on sperm parameters and pregnancy rates in vivo in controlled clinical trials. Empiric treatment of male infertility is generally not recommended.
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Class |
Drugs |
Effect |
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|
Antiestrogen |
Clomiphene citrate Tamoxifen |
Prevent negative feedback of estrogens to the pituitary and hypothalamus
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Aromatase inhibitors |
Testolactone |
Block the conversion of testosterone to estrogen
|
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Mast cell blockers |
Tranilast |
Blocking release of chemical mediators from mast cells |
|
|
a-blockers |
Terazosin |
increase the rate of sperm transport from caput to cauda. Increase sperm concentration |
|
|
Gonadotropins/GnRH |
HCG/HMG, GnRH, Recombinant human FSH |
Possible effect on spermatogenesis and sperm maturation
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Pancreatic proteinase |
Kallikrein |
Cleaves kininogen to produce kinins( regulation of sperm motility)
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ACE inhibitors |
Captopril |
Increase sperm count |
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|
Prostaglandin inhibitors |
Indomethacin |
Block negative regulatory effect of prostaglandin on testicular and spermatozoal function
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|
Phosphodiesterase inhibitors |
Pentoxyfilline |
Increase sperm motility in vitro
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Corticosteroids |
Prednisone |
Anti-inflammatory effect
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Zinc |
Zinc |
Improve sperm production
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Vitamins |
C, E |
Antioxidants, decrease level of Reactive Oxygen Species |
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Aminoacids |
L-arginine |
Improve sperm motility |
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